منابع مشابه
Matrix metalloproteinases: not-so-innocent bystanders in heart failure.
For decades, the classic teaching of the pathophysiology of heart failure has focused, quite reasonably, on the inside of the cardiac myocyte. The dynamic states of the contractile proteins and exquisite controls of intracellular calcium movements coordinate myocardial contraction and relaxation and appeared to be prime suspects in all forms of systolic and diastolic dysfunction. Furthermore, m...
متن کاملMitochondria in cancer: not just innocent bystanders.
The first half of the 20th century produced substantial breakthroughs in bioenergetics and mitochondria research. During that time, Otto Warburg observed abnormally high glycolysis and lactate production in oxygenated cancer cells, leading him to suggest that defects in mitochondrial functions are at the heart of malignant cell transformation. Warburg's hypothesis profoundly influenced the pres...
متن کاملScaffolding Proteins: Not Such Innocent Bystanders
Sequential transfer of information from one enzyme to the next within the confines of a protein kinase scaffold enhances signal transduction. Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay.
متن کاملCancer-associated fibroblasts – Not-so-innocent bystanders in metastasis to bone?
Metastatic dissemination of cancer cells to local and distant sites such as bone requires a complex interaction of cancer cells with their surrounding microenvironment to allow invasion, immune evasion and spread via the vascular or lymphatic systems. The tumour microenvironment is composed of an array of cells embedded in a complex extracellular matrix (ECM) (Fig. 1). The predominant cell type...
متن کاملCell Regulation: Innocent bystanders or chosen collaborators?
Cyclins and cyclin-dependent kinases turn out to hve diverse functions, not all directly concerned with the cell cycle; do they provide a link between cell-cycle control and other cellular processes?
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2014
ISSN: 0028-0836,1476-4687
DOI: 10.1038/505492a